Publications

• Zifkos K, Bochenek ML, Gogiraju R, Robert S, Pedrosa D, Kiouptsi K, Moiko M, Poncelet P, Münzel T, Ruf W, Reinhardt C, Panicot-Dubois L, Dubois C, Schäfer K. Endothelial Protein Tyrosine Phosphatase-1 Deletion Promotes SNAP23 Phosphorylation Facilitating Von Willebrand Factor Exocytosis and Venous Thromboinflammation. Circulation Research. Accepted
• Lemmens TP*, Bröker V*, Rijpkema M, Hughes CCW, Schurgers LJ, Cosemans JMEM. Fundamental considerations for designing endothelialized in vitro models of thrombosis. Thromb Res. 2024 Mar. *Authors contributed equally.
• Provenzale I*, Solari FA*, Schönichen C*, Brouns SLN, Fernández DI, Kuijpers MJE, van der Meijden PEJ, Gibbins JM, Sickmann A, Jones C, Heemskerk JWM. Endothelium-mediated regulation of platelet activation: Involvement of multiple protein kinases. FASEB J. 2024 Feb. *Authors contributed equally
• Mohapatra AK, Todaro AM, Castoldi E. Factor V variants in bleeding and thrombosis. Res Pract Thromb Haemost. 2024 Jan
• Baidildinova G, Pallares Robles A, Ten Cate V, Kremers BMM, Heitmeier S, Ten Cate H, Mees BME, Spronk HMH, Wild PS, Ten Cate-Hoek AJ, Jurk K. Plasma protein signatures for high on-treatment platelet reactivity to aspirin and clopidogrel in peripheral artery disease. Thromb Res. 2023 Oct
• Ten Cate V, Rapp S, Schulz A, Pallares Robles A, Jurk K, Koeck T, Espinola-Klein C, Halank M, Seyfarth HJ, Beutel ME, Schuster AK, Marini F, Hobohm L, Lankeit M, Lackner KJ, Ruf W, Münzel T, Andrade-Navarro MA, Prochaska JH, Konstantinides SV, Wild PS. Circulating microRNAs predict recurrence and death following venous thromboembolism. J Thromb Haemost. 2023 Oct
• Schönichen C, Montague SJ, Brouns SLN, Burston JJ, Cosemans JMEM, Jurk K, Kehrel BE, Koenen RR, Ní Áinle F, O'Donnell VB, Soehnlein O, Watson SP, Kuijpers MJE, Heemskerk JWM, Nagy M. Antagonistic Roles of Human Platelet Integrin αIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow. Arterioscler Thromb Vasc Biol. 2023 Sep
• Iding AFJ, Kremers BMM, Pallares Robles A, Ten Cate H, Ten Cate-Hoek AJ. Residual Venous Obstruction as an Indicator of Clinical Outcomes following Deep Vein Thrombosis: A Management Study. Thromb Haemost. 2023 Aug
• Danckwardt S, Trégouët DA, Castoldi E. Post-transcriptional control of haemostatic genes: mechanisms and emerging therapeutic concepts in thrombo-inflammatory disorders. Cardiovasc Res. 2023 Jul.
• Nagy M*, Robles AP*, Visser M, Koeck T, Ten Cate V, Ten Cate-Hoek AJ, Schwers S, Heitmeier S, Ten Cate H, Wild PS, Spronk HMH. Predictive value for increased activated factor XI activity in acute venous thromboembolism. J Thromb Haemost. 2023 Jun. *Authors contributed equally
• Gogiraju R, Witzler C, Shahneh F, Hubert A, Renner L, Bochenek ML, Zifkos K, Becker C, Thati M, Schäfer K. Deletion of endothelial leptin receptors in mice promotes diet-induced obesity. Sci Rep. 2023 May
• Pallares Robles A, Ten Cate V, Lenz M, Schulz A, Prochaska JH, Rapp S, Koeck T, Leineweber K, Heitmeier S, Opitz CF, Held M, Espinola-Klein C, Lackner KJ, Münzel T, Konstantinides SV, Ten Cate-Hoek A, Ten Cate H, Wild PS. Unsupervised clustering of venous thromboembolism patients by clinical features at presentation identifies novel endotypes that improve prognostic stratification. Thromb Res. 2023 May
• Leberzammer J, Agten SM, Blanchet X, Duan R, Ippel H, Megens RTA, Schulz C, Aslani M, Duchene J, Döring Y, Jooss NJ, Zhang P, Brandl R, Stark K, Siess W, Jurk K, Heemskerk JWM, Hackeng TM, Mayo KH, Weber C, von Hundelshausen P. Targeting platelet-derived CXCL12 impedes arterial thrombosis. Blood. 2022 Apr
• Zhang P, Solari FA, Heemskerk JWM, Kuijpers MJE, Sickmann A, Walter U, Jurk K. Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets. Int J Mol Sci. 2023 Apr
• Ten Cate V, Prochaska JH, Schulz A, Nagler M, Robles AP, Jurk K, Koeck T, Rapp S, Düber C, Münzel T, Konstantinides SV, Wild PS. Clinical profile and outcome of isolated pulmonary embolism: a systematic review and meta-analysis. EClinicalMedicine. 2023 Apr
• Akbalut C, Arisz R, Baaten C, Baildildinova G, Barakzie A, Bauersachs R, Ten Berg JM, van den Broek W, de Boer HC, Broker V, Buka R, Ten Cate H, Cate AT, De Luca C, De Simone I, Dignat-George F, Freson K, Gazzaniga G, van Gorp E, Habibi A, Henskens YMC, Iding AFJ, Khan A, Koenderink G, Konkoth A, Lacroix R, Lahiri T, Lam W, Lamerton R, Lorusso R, Luo Q, Maas C, McCarty OJT, van der Meijden P, Meijers J, Mohapatra A, Nevo N, Pallares Robles A, Poncelet P, Reinhardt C, Ruf W, Saraswat R, Schonichen C, Schutgens REG, Simioni P, Spada S, Spronk HMH, Tazhibayeva K, Thachil J, Vacik-Diaz R, Veninga A, Verhamme P, Visser C, Watson SP, Wenzel P, Willems R, Willers A, Zhang P, Zifkos K, van Zonneveld AJ. Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis. Thromb Haemost. 2023 Mar.
• Iding AFJ, Kremers BMM, Pallares Robles A, Ten Cate H, Cate AT. Residual venous obstruction as an indicator of clinical outcomes following deep vein thrombosis: a management study. Thromb Haemost. 2023 Mar.
• Iding AFJ*, Robles AP*, Ten Cate V, Ten Cate H, Wild PS, Ten Cate-Hoek AJ. Exploring phenotypes of deep vein thrombosis in relation to clinical outcomes beyond recurrence. J Thromb Haemost. 2023 Feb. *Authors contributed equally
• Koenen RR. Platelets: from simple fragments to inflammation regulators. Eur Heart J. 2023 Feb
• Iding AFJ, Kremers BMM, Nagy M, Robles AP, Ten Cate H, Spronk HMH, Ten Cate-Hoek AJ. Translational insights into mechanisms underlying residual venous obstruction and the role of factor XI, P-selectin and GPVI in recurrent venous thromboembolism. Thromb Res. 2023 Jan.
• Baidildinova G, Ten Cate V, Nagler M, Panova-Noeva M, Rapp S, Köck T, Prochaska JH, Heitmeier S, Gerdes C, Schwers S, Konstantinides SV, Münzel T, Espinola-Klein C, Lackner KJ, Spronk HMN, Ten Cate H, van der Meijden PEJ, Leineweber K, Wild PS, Jurk K. Subtype-specific plasma signatures of platelet-related protein releasate in acute pulmonary embolism. Thromb Res. 2022 Dec.
• Luo Q, Wenzel P. Properdin (factor P) as a new target cleaved by factor XIa: Intrinsic coagulation at the crossroads with inflammation. Res Pract Thromb Haemost. 2022 Nov.
• Kremers BMM, Posma JN, Heitmeier S, Glunz J, Ten Cate H, Pallares Robles A, Daemen JHC, Ten Cate-Hoek AJ, Mees BME, Spronk HMH. Discovery of four plasmatic biomarkers potentially predicting cardiovascular outcome in peripheral artery disease. Sci Rep. 2022 Nov.
• Pallares Robles A, Ten Cate V, Schulz A, Prochaska JH, Rapp S, Koeck T, Panova-Noeva M, Heitmeier S, Schwers S, Leineweber K, Seyfarth HJ, Opitz CF, Spronk H, Espinola-Klein C, Lackner KJ, Münzel T, Andrade-Navarro MA, Konstantinides SV, Ten Cate H, Wild PS. Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis. Sci Rep. 2022 Jun.
• Leberzammer J, Agten SM, Blanchet X, Duan R, Ippel H, Megens RTA, Schulz C, Aslani M, Duchene J, Döring Y, Jooss NJ, Zhang P, Brandl R, Stark K, Siess W, Jurk K, Heemskerk JWM, Hackeng TM, Mayo KH, Weber C, von Hundelshausen P. Targeting platelet-derived CXCL12 impedes arterial thrombosis. Blood. 2022 Apr.
• Spada S, Luke B, Danckwardt S. The Bidirectional Link Between RNA Cleavage and Polyadenylation and Genome Stability: Recent Insights From a Systematic Screen. Front Gen. 2022 Apr.
• Huang J, Zhang P, Solari FA, Sickmann A, Garcia A, Jurk K, Heemskerk JWM. Molecular Proteomics and Signalling of Human Platelets in Health and Disease. Int J Mol Sci. 2021 Sep.
• Zifkos K, Dubois C, Schäfer K. Extracellular Vesicles and Thrombosis: Update on the Clinical and Experimental Evidence. Int. J. Mol. Sci. 2021 Aug.
• van Gorp RH, Baaten CCFMJ, Habibi A, Jaminon AMG, Peeters FECM, Leenders P, Crijns HJGMC, Heemskerk JWM, Reutelingsperger CP, Spronk HM, Schurgers LJ. Vitamin K antagonist use induces calcification and atherosclerotic plaque progression resulting in increased hypercoagulability. Eur Heart J Open. 2021 Aug.
• Baidildinova G, Nagy M, Jurk K, Wild PS, ten Cate H, van der Meijden PEJ. Soluble platelet release factors as biomarkers for cardiovascular disease. Front Cardiovasc Med (Thrombosis). 2021 Jun.
• van Gorp RH, Dijkgraaf I, Bröker V, Bauwens M, Leenders P, Jennen D, Dweck MR, Bucerius J, Briedé JJ, van Ryn J, Brandenburg V, Mottaghy F, Spronk HM, Reutelingsperger CP, Schurgers LJ. Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate. J Thromb Haemost. 2021 Mar.
• Konkoth A, Saraswat R, Dubrou C, Sabatier F, Leroyer AS, Lacroix R, Duchez AC, Dignat-George F. Multifaceted role of extracellular vesicles in atherosclerosis. Atherosclerosis. 2021 Feb.
• Ten Cate V, Prochaska JH, Schulz A, Koeck T, Pallares Robles A, Lenz M, Eggebrecht L, Rapp S, Panova-Noeva M, Ghofrani HA, Meyer FJ, Espinola-Klein C, Lackner KJ, Michal M, Schuster AK, Strauch K, Zink AM, Laux V, Heitmeier S, Konstantinides SV, Münzel T, Andrade-Navarro MA, Leineweber K, Wild PS. Protein expression profiling suggests relevance of noncanonical pathways in isolated pulmonary embolism. Blood. 2021 Feb.
• Makhoul S, Kumm E, Zhang P, Walter U, Jurk K. The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets. Int J Mol Sci. 2020 Nov.
• Nourse J, Spada S, Danckwardt S. Emerging Roles of RNA 3'-end Cleavage and Polyadenylation in Pathogenesis, Diagnosis and Therapy of Human Disorders. Biomolecules. 2020 Jun.

Awards

• Baidildinova G: Young Investigator Award. 5th Euro Spring School: The Science and Practice of Venous Thromboembolism. Crete, Greece, 2021.
• Baidildinova G: Young Investigator Award. 3rd TICARDIO Training, CARIM, University of Maastricht, The Netherlands. March 23-25, 2022.
• Bröker V: Harry Struijker-Boudier award for talented academics (HS-BAFTA), CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands, 2022.
• Bröker V: Young investigator award, 3rd TICARDIO Conference, Marseille, France. March 15-17, 2023.
• Bröker V: Science Communication Award 2023. 3rd TICARDIO Conference, Marseille, France. March 15-17, 2023.
• Bröker V: Young investigator award, 3rd TICARDIO Conference, Marseille, France. March 15-17, 2023.
• Habibi A: Young investigator award, 3rd TICARDIO Conference, Marseille, France. March 15-17, 2023.
• Luo Q: Early Career Travel Award, ISTH Montreal, Canada, 2023.
• Mohapatra A: Young Investigators Award: ECTH 2023 congress (September 13-15, 2023), Valencia, Spain.
• Pallares Robles A: Young Investigator Award. 3rd TICARDIO Training, CARIM, University of Maastricht, The Netherlands. March 23-25, 2022.
• Pallares Robles A: Young Investigators Award: ECTH 2023 congress (September 13-15, 2023), Valencia, Spain
• Saraswat R: Young Investigator Award. 3rd TICARDIO Training, CARIM, University of Maastricht, The Netherlands. March 23-25, 2022.
• Schönichen C: Early Career Travel Award, ISTH 2021
• Spada S: Early Career Travel Award, ISTH Montreal, Canada, 2023.
• Vacik Diaz R: Young investigator award, 3rd TICARDIO Conference, Marseille, France. March 15-17, 2023.
• Vacik Diaz R: Early Career Travel Award, ISTH Montreal, Canada, 2023.
• Vacik Diaz R: Oral communication at the ISTH Montreal selected among 10 abstracts presented at the Highlights Plenary. ISTH Montreal, Canada, 2023.
• Zhang P: Santander Scholarship: International Stays 2023 (Travel Grant)
• Zifkos K: Award of “Highly Cited paper” by the International Journal of Molecular Sciences for Review paper (doi: 10.3390/ijms22179317). 2021.
• Zifkos K: Early Career Travel Award, ISTH London, UK, 2022.